Research shows granddaughters and great-granddaughters of pre-puberty smokers have more body fat than expected

Bristol (England) [UK], January 22 : A new study, led by the University of Bristol, has reported increased body fat in females whose grandfathers or great-grandfathers began smoking before puberty.
The results were published in 'Scientific Reports'.
Experiments with model studies elsewhere showed that exposure of males to certain chemicals before breeding can have effects on their offspring. There has, however, been doubt as to whether this phenomenon was present in humans and whether any apparent effects might be more readily explained by other factors.
To investigate the effects of prepubertal exposures in humans, scientists from the University of Bristol studied the possible effects of ancestral prepubertal cigarette smoking on participants in the Children of the 90s, a study of over 14,000 individuals. In earlier research from 2014, they found that if a father started smoking regularly before reaching puberty (before 11 years of age), then his sons, but not his daughters, had more body fat than expected.
In the newly published study, they extended this analysis to earlier generations using recently collected data on the grandfathers and great-grandfathers of study participants obtained by questionnaires. They discovered higher body fat in females whose paternal grandfathers or great-grandfathers had started smoking before age 13 compared to those whose ancestors started smoking later in childhood (age 13 to 16). No effects were observed in the male descendants. Further research would be needed to confirm these observations in other longitudinal studies and to expand the investigation into other transgenerational effects and ancestral exposures.
Professor Jean Golding, lead author of the report, said: "This research provides us with two important results. First, that before puberty, exposure of a boy to particular substances might have an effect on generations that follow him. Second, one of the reasons why children become overweight may be not so much to do with their current diet and exercise, rather than the lifestyle of their ancestors or the persistence of associated factors over the years."
He further added, "If these associations are confirmed in other datasets, this will be one of the first human studies with data suitable to start to look at these associations and to begin to unpick the origin of potentially important cross-generation relationships. It is with great thanks to participants within the Children of the 90s study that we are able to carry out such pioneering research. There is much to explore."